![]() For example, a powder poured in to a cylinder will have a particular bulk density if the cylinder is disturbed, the powder particles will move and usually settle closer together, resulting in a higher bulk density. The total volume includes particle volume, inter-particle void volume and internal pore volume.īulk density is not an intrinsic property of a material it can change depending on how the material is handled. Material divided by the total volume they occupy. It is defined as the mass of many particles of the i) Bulk/Fluffy/Poured densityīulk density is a property of powders, granules and other “divided” solids, especially used in reference to pharmaceutical powder or soil. The bulk and tapped density of pharmaceutical powders are often measured for processability. There are a number of bulk properties of powders which are of importance because they give information on how a powder is likely to behave when it is being used in a process. Characterization of packing geometry Bulk properties The distribution of particles should be uniform in terms of number and weight. Good flow properties of granules and powders are important in the manufacturing of tablets and capsules. Smaller the size of the particle, better the physical stability of the dosage form owing to the brownian movement of the particles in the dispersion. Physical stability of the suspensions and emulsions. Micromeritic properties of a particle i.e the particle size in a formulation influences the The higher the dissolution, the faster the absorption and hence quicker and greater the drug action. Particle size and surface area influence the drug absorption and subsequently the therapeutic action. Higher surface area brings about intimate contact of the drug with the dissolution fluids in vivo and increases the drug solubility and dissolution. Particle size and surface area influence the release of a drug from a dosage form that is administered orally, rectally parenterally and topically. Applications of micromeritics Release and dissolution ![]() Chemical adsorption techniques are used to determine the active area of catalysts, metal dispersion, and surface energy. Physical adsorption and mercury porosimetry instruments determine surface area and porosity. Particle size analyzers employ laser diffraction, sedimentation, and electrozone sensing. ![]() Pharmacology, cosmetics, nanotechnology, paints, pigments, food science, ceramics, textiles, geological science, and polymer science are some of the areas of science and technology that rely on Micromeritics’ instruments to determine the physical characteristics of powders and solid materials. This knowledge is essential in the development of products, the efficient utilization of raw materials, and the understanding of many natural phenomena. Particle size, surface area, pore size, material density, and active surface area are characteristics that are crucial to the understanding of a variety of materials. The successful formulation of suspensions, emulsions and all tablets both physical stability and pharmacologic response also depends on the particle size achieved in the product. Clinically, the particle size of a drug can affect its release from dosage forms that are administered orally, parenterally, rectally and topically. The size, and hence the surface area of a particle, can be related to the physical, chemical and pharmacologic properties of drugs. The knowledge and control of the size of particles is of importance in pharmacy and materials science. Micromeritics is the science and technology of small particles in the micrometre range.
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